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Please see the Down Syndrome and Cytogenetics Models Resource for more information. This strain has been maintained by continuous crossing of a Ts65Dn trisomic female to the Stock No. About 15% of the distal end of chromosome 16 is fused to less than 10% of the centromeric end of chromosome 17 to form a small translocation chromosome.The translocation breaks mouse Chr 16 just proximal to the amyloid precursor protein ( App ) gene and contains the HSA21-homologous genes from App to the telomere.
Animals are typically ready to ship in 11-14 weeks.
An attribute that distinguishes this line from Stock No. Specifically, these mice are homozygous for the wild-type allele of and thus all of the trisomic mice generated can be utilized in studies without the complication of retinal degeneration.
The precise locations of the Chr 16 and Chr 17 breakpoints are 84,351,351 bp and 9,426,822 bp, respectively.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Terms are granted by individual review and stated on the customer invoice(s) and account statement. The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations.